Title

• Liver metabolism and metformin action in type 2 diabetes  
  J. Radziuk and S. Pye

    1

• Metformin and the gut function  
  Gilles Mithieux

    31

• Mechanisms and determinants of metformin action on glucose transport  
  N. Wiernsperger

    41

• Metformin action on the insulin receptor, other tyrosine kinases and phosphatases  
  Bradley J. Stith

    59

• Metformin and the AMP-activated protein kinase  
  Bruno Guigas and Louis Hue

    81

• Metformin and vasculo-protection: Clinical aspects  
  L. G. Kraemer-Aguiar and E. Bouskela

    111

• Metformin as a cardiovascular drug: Evidences, mechanisms and insight into safety  
  Rapin JR and Wiernsperger NF

    131

• Microcirculation: A unique target for metformin  
  E. Bouskela and N. Wiernsperger

    163

• Anti-hyperglycemic action and vasculo-protection by metformin: A consequence of its anti-oxidative properties?  
  Peter Rösen

    187

• Insulin resistance and metformin therapy in polycystic ovary syndrome patients  
  Alexandra Crand, Kevin Hogeveen and Michel Pugeat

    213

• Nonalcoholic fatty liver disease and metformin  
  Philippe André

    227

• Metformin in oncology, new clinical potential for an old remedy?  
  Marc Billaud and Benoit Viollet

    241